
New manuscript: PARG inhibitors part 2
Delighted to bring you a hot-off-the-press story, a manuscript that we have deposited on Biorxiv. Dr Cam Coulson-Gilmer, a post-doc in the team, has performed a detailed characterisation of 10 ovarian cancer cell lines in response to a PARG inhibitor, segregating them into six that are resistant and four are sensitive. Cam shows that sensitivity correlates with several markers of persistent DNA replication stress, and using Nanostring technology she shows that the PARGi-sen