Search
Stephen Taylor
- Jul 17, 2020
- 1 min
New manuscript: Classification of ovarian cancer cell lines
Another hot-off-the-press story deposited on Biorxiv. In this study, Dr Beth Barnes, a post-doctoral research associate in the team applied her bioinformatics and machine learning skills to apply non-negative matrix factorisation (NMF) to the transcriptional profiles of 45 commonly used ovarian cancer cell lines and shows that this exquisitely clusters them into five distinct classes, representative of the five main subtypes of EOC. This analysis will facilitate selection of
30 views0 comments
Stephen Taylor
- Jul 17, 2020
- 1 min
New manuscript: Synthesis and comparison of Bub1 inhibitors
Congratulation to Ilma Amalina, not only has she successfully defended her PhD thesis but her thesis work is now available on Biorxiv. We have had a long standing interest in the Bub1, a serine/threonine kinase involved in both the spindle assembly checkpoint (SAC) and mitotic chromosome alignment. It is well documented that Bub1 phosphorylates Histone 2A at T120 (H2ApT120) which is required for recruitment of Sgo1 to centromeres. Small-molecule inhibitors are invaluable tool
45 views0 comments